发明名称 |
HOLLOW NANOPARTICLE HAVING MODIFIED CYSTEINE RESIDUE AND DRUG WITH THE USE THEREOF |
摘要 |
The invention provides hollow nanoparticles of a protein with the ability to recognize specific cells such as the hepatocytes and to form particles (for example, hepatitis B virus surface-antigen protein), wherein the protein has a cysteine residue substituted to a different amino acid. The hollow nanoparticles have a stable particle structure and can be used to efficiently transfer substances to specific target cells or tissues. The invention also provides a drug using the hollow nanoparticles.
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申请公布号 |
EP1541135(A1) |
申请公布日期 |
2005.06.15 |
申请号 |
EP20030761834 |
申请日期 |
2003.06.27 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY |
发明人 |
KURODA, SHUNICHI;TANIZAWA, KATSUYUKI;KONDO, AKIHIKO;UEDA, MASAKAZU;SENO, MASAHARU;TADA, HIROKO |
分类号 |
C12N15/09;A61K9/51;A61K38/00;A61K47/42;A61K48/00;A61P1/16;A61P35/00;A61P43/00;C07K14/02;C12N1/19;C12N5/10;C12N15/88;(IPC1-7):A61K9/51 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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