发明名称 |
VERFAHREN ZUR HERSTELLUNG PHARMAKOLOGISCH VERTRÄGLICHER SALZE VON N-(1(S)-ETHOXYCARBONYL-3- PHENYLPROPYL)-L-ALANYL AMINOSÄUREN |
摘要 |
<p>Preparation of salts of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl amino acid derivatives of formula (R1)NH-CH(R2)-CO2H (I) comprises: (a) condensing an amino acid with N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine N-carboxyanhydride of formula (II), under basic conditions; (b) decarboxylating the condensate under neutral to acidic conditions to give (I); and (c) and converting (I) to its salt. Steps (a), (b) and optionally (c) are carried out in aqueous liquid to inhibit the formation of by-products of formula (III): -N(R1)CH(R2)-C(O)- = e.g. group of formula (i).</p> |
申请公布号 |
AT296311(T) |
申请公布日期 |
2005.06.15 |
申请号 |
AT19980932585T |
申请日期 |
1998.07.21 |
申请人 |
KANEKA CORPORATION |
发明人 |
UEDA, YASUYOSHI;KINOSHITA, KOICHI;MOROSHIMA, TADASHI;YANAGIDA, YOSHIFUMI;FUSE, YOSHIHIDE |
分类号 |
A61P9/12;C07K1/02;C07K1/08;C07K5/02;C07K5/06;C07K5/062;(IPC1-7):C07K5/062 |
主分类号 |
A61P9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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