发明名称 |
Processing method of lactionization in the preparation of statins |
摘要 |
The present invention relates to a processing method for preparing lovastatin and simvastatin which comprises the steps of (1) performing lactonization of mevinic acid and its homologous compounds in the presence of a mixed organic solvent without an acid catalyst through nitrogen sweep; and (2) making crystals. In the process of the present invention, lovastatin and simvastatin highly purified can be produced in a high yield and especially, heterodimers formed as a by-product can be reduced remarkably. Therefore, the processing method of the present invention can be convenient and economical.
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申请公布号 |
US6906204(B2) |
申请公布日期 |
2005.06.14 |
申请号 |
US20020295300 |
申请日期 |
2002.11.14 |
申请人 |
CJ CORP. |
发明人 |
LEE KWANG-HYEG;KIM JIN-WAN;CHOI KWANG-DO;LEE SANG-HO;CHO HONG-SUK |
分类号 |
C07D309/10;A61K31/366;A61P3/06;A61P43/00;C07D309/30;(IPC1-7):C07D309/10 |
主分类号 |
C07D309/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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