| 发明名称 |
Triarylimidazole derivatives as cytokine inhibitors |
| 摘要 |
Compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein R<SUB>1</SUB>, R<SUB>2 </SUB>and R<SUB>3 </SUB>are various substituent groups; and one of X<SUB>1 </SUB>and X<SUB>2 </SUB>is N or CR'', and the other is NR'' or CHR'' wherein R'' is hydrogen, OH, C<SUB>1-6</SUB>alkyl, or C<SUB>3-7</SUB>cycloalkyl; or when one of X<SUB>1 </SUB>and X<SUB>2 </SUB>is N or CR'' then the other may be S or O; and their use as pharmaceuticals.
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| 申请公布号 |
US6906089(B2) |
申请公布日期 |
2005.06.14 |
| 申请号 |
US20030239815 |
申请日期 |
2003.01.21 |
| 申请人 |
SMITHKLINE BEECHAM CORPORATION |
发明人 |
GASTER LARAMIE MARY;HARLING JOHN DAVID |
| 分类号 |
A61K31/4178;A61K31/4439;A61K31/498;A61P1/04;A61P3/10;A61P9/04;A61P9/10;A61P13/12;A61P17/02;A61P19/02;A61P19/10;A61P25/28;A61P27/02;C07D401/04;C07D401/14;C07D405/14;C07D413/04;C07D413/14;C07D417/14;(IPC1-7):A61K31/443;A61K31/443;C07D405/04 |
主分类号 |
A61K31/4178 |
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