发明名称 |
Effective nuclear reprogramming in mammals using CDK2 inhibitors |
摘要 |
The present invention provides methods of producing a cloned non-human mammalian nuclear transfer (NT) embryo and methods for producing a cloned non-human mammal. Embodiments of the methods include introducing donor genetic material into a metaphase I oocyte; introducing donor genetic material into a non-enucleated oocyte; introducing donor genetic material obtained from a donor cell that is at metaphase into an oocyte; introducing donor genetic material into an oocyte, and naturally activating the oocyte or the NT embryo; and introducing donor genetic material obtained from a donor cell that is at late G1 phase into an oocyte.
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申请公布号 |
US6906238(B2) |
申请公布日期 |
2005.06.14 |
申请号 |
US20010809662 |
申请日期 |
2001.03.15 |
申请人 |
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. |
发明人 |
STICE STEVEN |
分类号 |
C12N15/873;(IPC1-7):C12N15/00;C12N5/02;A01K67/027 |
主分类号 |
C12N15/873 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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