Process for preparing clavam derivatives by using polypeptides having beta-lactam synthetase activity

摘要

The present invention relates to a new process for the synthesis of clavam compounds, in particular clavulanic acid. In one aspect, the invention relates to Streptomyces clavuligerus beta-lactam synthetase polypeptide sand Streptomyces clavuligerus beta-lactam synthetase polynucleotides, recombinant materials thereof and methods for their production. In another aspect, the invention relates to methods for using such polypeptides and polynucleotides.