LIPOSOMES AND LIPOSOME VESICLE PRECURSORS WITH POROUS EXPANDED STRUCTURE

摘要

The invention relates to a dry deposit as a precursor to liposome vesicles, the precursor being a three-dimensional expanded structure with bulk density between .01 and .001 g/cm3. The invention also concerns a method of making liposome vesicles with an enhanced entrapment capacity by dissolving one or more film forming lipids in at least one organic solvent to form a solution in a reaction vessel, evaporating the solvent to form an expanded three dimensional porous lipid structure, contacting the lipid deposit with an aqueous carrier phase, and producing liposome vesicles entrapping the carrie r phase as well as an apparatus comprising an array of tubing or an inert packing which serves as a material support or a matrix surface for the deposition of lipids produced according to the method.