发明名称 |
СПОСОБ ПОЛУЧЕНИЯ 7-ЗАМЕЩЕННОГО-3-ХИНОЛИН И 3-ХИНОЛ-4-ОН КАРБОНИТРИЛОВ |
摘要 |
There is provided a process for the preparation of 7-substituted-3-quinolinecarbonitriles and intermediates useful in a process to prepare 7-substituted-3-quinolinecarbonitriles and pharmaceutically acceptable salts is described. Where 7-fluoro-4-oxo-1,4-dihydro-3-quinolinecarbonitrile is converted in three steps to 7-substituted-3-quinolinecarbonitriles which inhibit the action of certain protein kinases and are useful in the treatment of cancer. |
申请公布号 |
RU2004134735(A) |
申请公布日期 |
2005.06.10 |
申请号 |
RU20040134735 |
申请日期 |
2003.04.29 |
申请人 |
УАЙТ ХОЛДИНГЗ КОРПОРЕЙШН (US) |
发明人 |
БОСКЕЛЛИ Дайан Харрис (US);ВАНГ Йанонг Дэниел (US);ДЖОНСОН Стивен Лоренс (US);БЕРГЕР Дэн Мартен (US) |
分类号 |
A61K31/4704;A61K31/4709;A61K31/554;A61P35/00;A61P43/00;C07D215/22;C07D215/54;C07D215/56;C07D401/12;C07D401/14;C07D405/12;C07D409/12;C07D417/12 |
主分类号 |
A61K31/4704 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|