| 摘要 |
The present invention provides methods for identifying monobactams with anti-PBP2a activity. The method involves the selection of RNA biocatalysts that promote the formation of monobactams with anti-PBP2a activity from component reactants. The invention also provides novel monobactams with anti-PBP2a activity identified by these methods. The invention also provides RNA biocatalysts that are capable of catalyzing the formation of monobactams from component reactants.
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