摘要 |
The present invention relates to compounds of formula (I); and pharmaceutically acceptable salts thereof, in which R<1> and R<2> independently represent phenyl, thienyl, pyridyl, C1-10alkyl, C1-10alkoxy or C3-15cycloalkyl ; R<3> represents a C1-15alkyl group, C3-15cycloalkyl, a phenylC1-4alkyl group, a heteroaryl group, a heteroarylC1-4alkyl group, or a group R<4>(CH2)n- in which R<4> represents a saturated or partially unsaturated 5 to 8 membered heterocyclic group containing one or more heteroatoms selected from nitrogen, oxygen or sulphur and n is 0, 1, 2, 3 or 4; X and Y independently represent O or S; m and n independently represent 0 or 1; wherein each of R<1>, R<2>, R<3> and R<4> is optionally substituted by one, two or three groups represented by Z wherein Z represents a C1-6alkyl group optionally substituted by one or more fluoro, a C1-6alkoxy group optionally substituted by one or more fluoro, hydroxy, halo, trifluoromethylsulphonyl, benzyl, nitro, amino, mono or di C1-4alkylamino, mono or di C1-3alkylamido, C1-3alkylsulphonyl, C1-6alkoxycarbonyl, carboxy, cyano, carbamoyl, mono or di C1-3alkyl carbamoyl, sulphamoyl or acetyl and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them. |