发明名称 |
Developmental animal model of temporal lobe epilepsy |
摘要 |
Disclosed is a developmental animal model of temporal lobe epilepsy and other seizure-related disorders. In particular, the invention provides a method of inducing a permanent change in the neurological development of a rodent, such as a rat, comprising daily administration of low doses of a kainate receptor agonist to the animal in the second postnatal week, wherein after treatment with the kainate receptor agonist the animal exhibits reproducible seizure-like symptoms when exposed to mild to moderate stressors. Rats treated using the above method are particularly useful as a non-human system for studying temporal lobe epilepsy, as well as for studying the efficacy of potential anti-epileptic compounds and pharmaceutical preparations.
|
申请公布号 |
US2005124695(A1) |
申请公布日期 |
2005.06.09 |
申请号 |
US20030728357 |
申请日期 |
2003.12.04 |
申请人 |
DOUCETTE TRACY;BAK-JENSEN HENRIETTE H.;PERRY MELISSA;RYAN CATHERINE;TASKER R. ANDREW |
发明人 |
DOUCETTE TRACY;BAK-JENSEN HENRIETTE H.;PERRY MELISSA;RYAN CATHERINE;TASKER R. ANDREW |
分类号 |
A01K67/027;A01N37/12;A61K31/198;A61K31/40;C12Q1/00;(IPC1-7):A01K67/027 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|