CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND CORTICOTROPIN RELEASING FACTOR ANTAGONIST COMPOSITIONS FOR TREATING ISCHEMIC MEDIATED CNS DISORDERS OR INJURIES

摘要

The present invention provides compositions and methods for the treatment of ischemic mediated central nervous system disorder or injury. More particularly, the invention provides a combination therapy for the treatment of a central nervous system ischemic mediated disorder or injury comprising the administration to a subject of a cyclooxygenase-2 selective inhibitor and a corticotropin releasing factor antagonist or a pharmaceutically acceptable salt or a prodrug thereof.