SURFACE DISPLAY EXPRESSION SYSTEM

摘要

The present invention provides a biological surface display expression system for the on-line detection of stress-inducing or toxic compounds. The system relies on the expression of a chimeric gene under the control of a progressively-inducible promoter in a host cell. The system may also rely on the expression of a chimeric gene comprising a hotspot sequence under the control of a progressively-inducible promoter in a host cell. In another aspect, the present invention also relates to a method, using said biological reporter system for identifying and characterizing stress-inducing compounds. In a further aspect, the present invention relates to diagnostic kits for performing any of the methods according to the present invention.