| 摘要 |
A labeled polynucleotide is subjected to hybridization with oligonucleotide probes fixed respectively to regions on a supporting material. With a restriction enzyme, a single-stranded moiety of the labeled polynucleotide having failed to form a double strand with each probe is separated from a double strand having been formed by the labeled polynucleotide and each probe. Thereafter, an electrode is located at a surface of each region on the supporting material, and a voltage is applied to the electrode. The labeled polynucleotide, which has undergone a mismatch binding with a certain oligonucleotide probe, is thus separated from the corresponding region on the supporting material.
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