METHOD OF CULTURING CD4-POSITIVE T CELLS VIA STIMULATION CULTURE OF HIV-1-INFECTED PHERIPHERAL MONOCYTES AND HIV-1 GROWTH INHIBITOR

摘要

[PROBLEMS] To provide a method for stably culturing and proliferating CD4-positive T cells collected from an AIDS patient infected with R5 HIV-1 with the use of CCR5 as a corecepotr, X4 HIV-1 with the use of CXCR4 and R5/X4-HIV-1 with the use of both of CCR5 and CXCR4. [MEANS FOR SOLVING PROBLEMS] An HIV-1 growth inhibitor containing a compound of the following formula I or its salt; and a method of culturing CD4-positive T cells characterized by culturing HIV-1-inefected peripheral monocytes by using this inhibitor: V-CR<1>R<2>-Ar-CR<3>R<4>-N(R<5>)-(CR<6>R<7>)x-R<8> (I) wherein V represents a 9- to 24-membered cyclic polyamine moiety having 2 to 6 amine nitrogen atoms in which these amine nitrogen atoms are located at intervals of at least 2 carbon atoms from each other; R<1> to R<7> independently represent each a group selected from the group consisting of a hydrogen atom and linear, branched and cyclic C1-6 alkyls; and R<8> is a monocyclic or polycyclic heterocycle group or a monocyclic or polycyclic group.