Process for preparation of substituted amino alcohols

摘要

There is provided a process for the preparation of substituted amino alcohols HO-(CH₂)_n-NR¹R² from haloalcohols HO-(CH₂)_n-X, where X is Cl, Br or I, by reaction with an amine HNR¹R², in water as solvent at a temperature range of about 20° C. to about 90° C. optionally in the presence of a catalytic amount of an iodide source metal iodides. The haloalcohols are useful in the preparation of 6-[(substituted)phenyl]-triazolopyrimidine compounds which are useful in the treatment of cancer.