THREE DIMENSIONAL CELL CULTURES IN A MICROSCALE FLUID HANDLING SYSTEM
摘要
The present invention provides a novel microscale fluid handling system for initiating, culturing, manipulating and assaying three-dimensional multicellular assembly. The system including a microfluidic device and three-dimensional multicellular tissue surrogate assembly. The device of the invention includes at least one microfluidic channel; and at least one chamber, wherein the walls of the chamber are lined with a cell layer; and wherein fluid medium flows through each of the channels and chambers. Also, disclosed are methods for using the device to introducing test agents to the multicellular assemblies to observe biological responses thereof.
申请公布号
WO2004101743(A3)
申请公布日期
2005.06.09
申请号
WO2004US14092
申请日期
2004.05.06
申请人
BELLBROOK LABS, LLC;LOWERY, ROBERT, G.;MAJER, JOHN;BEEBE, DAVID, J.