| 发明名称 |
Prodrugs of phosphonate nucleotide analogues |
| 摘要 |
A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided. |
| 申请公布号 |
US2005124584(A1) |
申请公布日期 |
2005.06.09 |
| 申请号 |
US20050031251 |
申请日期 |
2005.01.06 |
| 申请人 |
BECKER MARK W.;CHAPMAN HARLAN H.;CIHLAR TOMAS;EISENBERG EUGENE J.;HE GONG-XIN;KERNAN MICHAEL R.;LEE WILLIAM A.;PRISBE ERNEST J.;ROHLOFF JOHN C.;SPARACINO MARK L. |
发明人 |
BECKER MARK W.;CHAPMAN HARLAN H.;CIHLAR TOMAS;EISENBERG EUGENE J.;HE GONG-XIN;KERNAN MICHAEL R.;LEE WILLIAM A.;PRISBE ERNEST J.;ROHLOFF JOHN C.;SPARACINO MARK L. |
| 分类号 |
A61K31/664;A61K31/675;A61P31/12;A61P31/18;A61P35/00;C07F9/6561;C07H19/10;C07H19/20;C07H21/00;C12Q1/18;G01N33/15;G01N33/50;G01N33/53;(IPC1-7):A61K31/675 |
主分类号 |
A61K31/664 |
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