PROCESS FOR ENZYMATIC SYNTHESIS OF BetaEpsilonTauAlpha-LACTAM ANTIBIOTICS

摘要

The present invention describes a process for the preparation of beta-lactam antibiotics, cephalexin and ampicillin, wherein the beta-lactam nucleus is acylated with an acylating agent, D-phenylglycine, by means of a reaction biocatalyzed by a catalytic enzyme. The acylation reaction is carried out in solid phase in solvent free systems (water or organic solvents) for the dispersion of reagents and at controlled temperatures.