| 发明名称 |
Process for the preparation of a betha- lactam antibiotic with mutated penicillin acylase |
| 摘要 |
The invention relates to mutated penicillin acylases having a high synthesis/hydrolysis ratio in comparison with wild-type penicillin acylases and at least 1% of the activity. The invention also relates to a process for the enzymatic preparation of a beta-lactam antibiotic from a beta-lactam nucleus and an activated side chain with the aid of mutated penicillin acylases.
|
| 申请公布号 |
US2005124029(A1) |
申请公布日期 |
2005.06.09 |
| 申请号 |
US20040499662 |
申请日期 |
2004.12.13 |
| 申请人 |
ALKEMA WYNAND B.L.;MOODY HAROLD M.;VAN DER LAAN JAN M.;VAN DOOREN THEODORUS JOHANNES G.M.;BOESTEN WILHELMUS HUBERTUS J. |
发明人 |
ALKEMA WYNAND B.L.;MOODY HAROLD M.;VAN DER LAAN JAN M.;VAN DOOREN THEODORUS JOHANNES G.M.;BOESTEN WILHELMUS HUBERTUS J. |
| 分类号 |
C12N1/21;C12N9/84;C12N15/55;(IPC1-7):C12P35/04;C07D501/14;C12N9/10 |
主分类号 |
C12N1/21 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
