PEPTIDICALLY BUFFERED FORMULATIONS FOR ELECTROTRANSPORT APPLICATIONS AND METHODS OF MAKING
摘要
<p>Methods for preparing compositions for use in electrotransport delivery systems. The method includes providing a drug solution comprising drug ions and associated counterions; adjusting the pH of the drug solution by contacting the drug solution with a ion exchange material first; separating the ion exchange material from the pH-adjusted drug solution; and buffering the pH-adjusted drug solution with a buffer. A peptidic buffer is preferably used. The methods result in compositions suitable for use in electrotransport delivery systems.</p>
申请公布号
WO2005051485(A1)
申请公布日期
2005.06.09
申请号
WO2004US39184
申请日期
2004.11.19
申请人
ALZA CORPORATION;RAUSER, DAVID;PADMANABHAN, RAMA;PHIPPS, JOSEPH, B.;CORMIER, MICHEL
发明人
RAUSER, DAVID;PADMANABHAN, RAMA;PHIPPS, JOSEPH, B.;CORMIER, MICHEL