| 发明名称 |
Method and medicament for inhibiting the expression of a defined gene |
| 摘要 |
<p>A new method to inhibit the expression of a predetermined target gene in a cell, comprises introducing an oligoribonucleotide with double stranded structure (dsRNA) or a vector coding for the dsRNA into the cell, where a strand of the dsRNA is at least in part complementary to the target gene. - ACTIVITY : Antiviral; cytostatic; anti-prion. - MECHANISM OF ACTION : Double stranded RNA inhibitor of gene expression.</p> |
| 申请公布号 |
EP1214945(B1) |
申请公布日期 |
2005.06.08 |
| 申请号 |
EP20020003683 |
申请日期 |
2000.01.29 |
| 申请人 |
ALNYLAM EUROPE AG |
发明人 |
KREUTZER, ROLAND DR.;LIMMER, STEFAN DR. |
| 分类号 |
C12N15/09;A61K9/127;A61K31/70;A61K31/713;A61K35/76;A61K38/00;A61K47/48;A61K48/00;A61P25/28;A61P31/12;A61P35/00;C12N15/11;(IPC1-7):C12N15/11 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
