发明名称 |
PROCESS FOR PRODUCING OPTICALLY ACTIVE ERYTHRO 3-CYCLOHEXYLSERINES |
摘要 |
The present invention relates to a process in which N-acyl form of DL-erythro 3-substituted serines represented by the following general formula (1): <CHEM> (wherein, R1 means an alkanoyl group having 1-10 carbons, a benzoyl group, a halogen-substituted alkanoyl group having 1-5 carbons or a halogen-substituted benzoyl group, and R2 means a phenyl group or a cyclohexyl group) is subjected to asymmetrical hydrolysis with L-aminoacylase or D-aminoacylase, thereby giving unreacted N-acyl-D-erythro 3-substituted serine in the case of L-aminoacylase or hydrolyzed D-erythro 3-substituted serine in the case of D-aminoacylase. The D-erythro forms are useful as an intermediate for medicines, for example, known to be useful as an anti-HIV drug (WO 01/40227). |
申请公布号 |
EP1538216(A1) |
申请公布日期 |
2005.06.08 |
申请号 |
EP20030795302 |
申请日期 |
2003.09.05 |
申请人 |
NIPPON KAYAKU KABUSHIKI KAISHA |
发明人 |
IKEO, TAKAYOSHI;YAMAMOTO, KEN-ICHI |
分类号 |
C07B53/00;C07B61/00;C07C227/20;C07C229/28;C07C233/47;C12N9/80;C12P13/06;C12P41/00 |
主分类号 |
C07B53/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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