发明名称 |
IMMUNOPOTENTIATING COMPOSITIONS |
摘要 |
Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that selects the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. <??>The compositions of the present invention that inhibits the function of PD-1, PD-L1, or PD-L2 are useful for cancer or infection treatment. |
申请公布号 |
EP1537878(A1) |
申请公布日期 |
2005.06.08 |
申请号 |
EP20030741154 |
申请日期 |
2003.07.02 |
申请人 |
ONO PHARMACEUTICAL CO., LTD.;HONJO, TASUKU |
发明人 |
HONJO, TASUKU;MINATO, NAGAHIRO;IWAI, YOSHIKO;SHIBAYAMA, SHIRO |
分类号 |
A61K45/00;A01K67/027;A61K31/00;A61K31/7088;A61K33/00;A61K35/00;A61K35/14;A61K38/17;A61K39/395;A61P31/00;A61P35/00;A61P35/04;A61P37/04;C07K14/705;C07K16/28;C07K16/46;C12N5/10;C12Q1/02;G01N33/50;G01N33/574 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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