| 摘要 |
The invention relates to compounds of formulas wherein R<SUP>1 </SUP>and R<SUP>2 </SUP>are independently from each other lower alkoxy, lower alkenyloxy, benzyloxy, hydroxy, -OCH(CH<SUB>3</SUB>)OC(O)-lower alkyl or -OCH<SUB>2</SUB>C(O)N(R<SUP>3</SUP>)(R<SUP>4</SUP>), with the proviso that only one of R<SUP>1 </SUP>or R<SUP>2 </SUP>may be hydroxy; R<SUP>3 </SUP>and R<SUP>4 </SUP>are independently from each other and signify hydrogen, lower alkyl, lower alkenyl or cycloalkyl; or R<SUP>1 </SUP>and R<SUP>2 </SUP>form together with the carbon atom, to which they are attached the linking group X, wherein X is -O(CH<SUB>2</SUB>)<SUB>n</SUB>CH-CH(CH<SUB>2</SUB>)<SUB>n</SUB>O- or -O(CH<SUB>2</SUB>)<SUB>m</SUB>O-; n is 1, 2 or 3; and m is 4-8, or a pharmaceutically acceptable salt of said compound. Compounds of the present invention can be used for the treatment of diseases where Serum Amyloid P Component depletion has a beneficial effect, in particular in the treatment or prevention of central and systemic amyloidosis.
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