Isoquinuclidine derivative process for producing the same, and medicinal composition containing the same

摘要

An isoquinuclidine derivative represented by the following general formula (I): (I) [wherein A₁ is methylene or carbonyl]: R₁ is hydrogen or methyl: R₂ is -(CH₂)_n-A₂-Ph (n is an integer of 0 to 3 and A₂ is a single bond or -O-): and R₃ is -COOH, -COOR₄, -COSR₄ (R₄ is lower alkyl, unsubstituted phenyl, or phenyl substituted by a lower alkyl, lower alkoxy, hydroxyl, methoxycarbonyl, ethoxycarbonyl, or trifluoromethanesulfonamide group or by a halogen atom), etc.] or a pharmaceutically acceptable salt of the compound. Also provided is an oral remedy for diabetes, which contains the compound and has hypoglycemic activity.