| 摘要 |
<p>The invention concerns microcapsules for reliably modified release and adapted to industrial reproduction of an active principle hardly water-soluble, other than anti-hyperglycemia agents Each of said microcapsules comprises a core of hardly soluble active principle and a coating film applied on the core. Their mean diameter is less than 1000 microns. The coating film contains a film-forming polymer (P1) insoluble in gastrointestinal tract fluids, a water-soluble polymer (P2), a plasticizer (PL), and optionally a lubricating surfactant (TA). Said coating film represents at least 4 % p/p of dry matter of their total weight, and its components P1, P2, PL satisfy the following characteristics: dry weight mass fraction of P1 relative to the total coating weight ranging between 40 and 90 %; dry matter weight fraction of PL/P1+P2 ranging between 15 and 60 %; dry matter weight fraction of PL/P1+PL ranging between 1 and 30 %. The invention also concerns the uses of said microcapsules in galenic formulation.</p> |
