发明名称 PRODUIT IMMUNOMODULATEUR OBTENU A PARTIR D'UNE CULTURE DE BIFIDOBACTERIUM ET COMPOSITIONS LE CONTENANT
摘要 Immunomodulator obtained from cultures of Bifidobacterium breveI-2219. Immunomodulator obtained from cultures of Bifidobacterium breveI-2219 by the following process: (1) the bifidobacterium is used to seed a aqueous substrate at pH 6 - 8 containing the following: lactoserum permeate, lactoserum protein hydrolysate, and lactose, (2) the bifidobacterium is then incubated under aerobic or anaerobic conditions at a temperature between 30 and 40 [deg] C, (3) the bifidobacterium is eliminated from the aqueous substrate, (4) the aqueous substrate is ultrafiltered at 100 - 300 kDa to give a concentrate, (5) the concentrate is dehydrated, (6) the dehydrated product is dissolved in a buffer solution, (7) it undergoes exclusion chromatography on a column giving a threshold of exclusion at 600 kDa, and (8) the filtered product is recovered. ACTIVITY : Immunomodulator; Antibacterial; Gastrointestinal-Gen.. No suitable biological data provided. MECHANISM OF ACTION : Clostridium perfringensantagonist.
申请公布号 FR2853908(B1) 申请公布日期 2005.06.03
申请号 FR20030004745 申请日期 2003.04.16
申请人 COMPAGNIE GERVAIS DANONE 发明人 PETAY VALERIE;LECROIX FRANCIS;PERRIN EMMANUEL;GONTIER CHARLES;BLAREAU JEAN PIERRE;ROMOND MARIE BENEDICTE;SINGER ELISABETH;ODOU MARIE FRANCOISE;DEMAILLY MULLIE CATHERINE
分类号 A61K35/74;A61K38/16;A61P37/02 主分类号 A61K35/74
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