METHODS FOR MODULATING THE TH2 IMMUNERESPONSE TO AN ANTIGEN BY ADDING OR REMOVING ACTIVATED CARBONYL GROUPS FROM THE ANTIGEN

摘要

A method of modifying an antigen to modify the Th2-type bias of the Thl/Th2-type immune response of an animal exposed to the antigen, the method comprising decreasing the number of reactive carbonyl groups present in the antigen so as to decrease the Th2-type bias; or increasing the number of reactive carbonyl groups present in the antigen so as to increase the Th2-type bias. A pharmaceutical composition comprising an antigen modified by the method of the invention or a vaccine according to the invention or a composition according to the invention and a pharmaceutically acceptable carrier. Use of an antigen modified by the method of the invention or a vaccine according to the invention or a composition according to the invention or a pharmaceutical composition according to the invention in the manufacture of a medicament for the prevention or treatment of a disease.