Isoxazoline derivatives useful as antimicrobials

摘要

Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, HET is an N-linked 5-membered, fully or partially unsaturated heterocyclic ring, or HET is an N-linked 6-membered di-hydro-heteroaryl ring; Q is, for example, Q1 or Q2: wherein R² and R³ are independently hydrogen or fluoro; T is selected from a range of groups, for example a group of the formula (TC7) wherein Rc is, for example, hydrogen, R¹³CO-, R¹³SO₂- or R¹³CS-; wherein R¹³ is, for example, optionally substituted (1-10C)alkyl or R¹⁴C(O)O(1-6C)alkyl wherein R¹⁴ is optionally substituted (1-10C)alkyl; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.