| 摘要 |
The present invention relates to peptide compounds which modulate the interaction of ICAM-1 and LFA-1, and in particular, function as inhibitors of the interaction of integrins, more particularly, LFA-1, and one or several distinct intercellular adhesion molecules (ICAMS), in particular ICAM-1, pharmaceutical compositions comprising effective amounts of these peptide compounds and methods for the treatment and/or prevention of related disease states and conditions which are mediated through ICAM-1/LFA-1 interactions, for example, the interaction of cellular adhesion molecules with integrins and/or the emigration of leukocytes from blood into tissue.
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