发明名称 |
Spatially-defined macrocycles incorporating peptide bond surrogates |
摘要 |
Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
|
申请公布号 |
US2005119169(A1) |
申请公布日期 |
2005.06.02 |
申请号 |
US20040911219 |
申请日期 |
2004.08.02 |
申请人 |
TRANZYME PHARMA INC. |
发明人 |
DESLONGCHAMPS PIERRE;DORY YVES;OUELLET LUC;VILLENEUVE GERALD;RAMASESHAN MAHESH;FORTIN DANIEL;PETERSON MARK;HOVEYDA HAMID;BEAUBIEN SYLVIE;MARSAULT ERIC |
分类号 |
A61K38/12;C07D491/02;C07K1/04;C07K5/00;C07K5/08;(IPC1-7):A61K38/12 |
主分类号 |
A61K38/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|