Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method

摘要

Compounds are provided which are useful as antidiabetic agents and antiobesity agents and have the structure wherein m is 0, 1 or 2; n is 0, 1 or 2; Q is C or N; A is (CH₂)_x where x is 1 to 5, or A is (CH₂)_x¹ where x¹ is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is -(CH₂)_x²-O-(CH₂)_x³- where x² is 0 to 5 and x³ is 0 to 5, provided that at least one of x² and x³ is other than 0; B is a bond or is (CH₂)_x⁴ where x⁴ is 1 to 5; X is CH or N; X₂ is C, N, O or S; X₃ is C, N, O or S; X₄ is C, N; O or S; X₅ is C, N, O or S; X₆ is C, N, O or S; provided that at least one of X₂, X₃, X₄ X₅ and X₆ is N; and at least one of X₂, X₃, X₄ X₅ and X₆ is C, and specifically excluding the structure(s) as shown below: where X₂-N, X₃-C, X₄-O or S, Z=O or a bond R¹ is H or alkyl; R² is H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; R^2a, R^2b and R^2c may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; and R³ and Y are as defined herein, which compounds are useful in treating diabetes and obesity.