发明名称 |
MUTANT LRP5/6 WNT-SIGNALING RECEPTORS IN CANCER DIAGNOSIS, PROGNOSIS AND TREATMENT |
摘要 |
A novel mutant form of lrp5 and lrp6 genes, the mutant LRP5 and LRP6 receptor proteins expressed therefrom, and a cell line which expresses the mutant LRP5 and/or LRP6 receptor proteins. Methods of diagnosing, prognosing and treating LRP5related diseases, specifically hyperparathyroidism and parathyroid tumors, and kits suitable for rapid on-site testing. Finally, methods of screening for agents capable of modulating the mutant LRP5 or LRP6 receptor proteins and pharmaceutical compositions comprising the selected agents. |
申请公布号 |
WO2005048913(A2) |
申请公布日期 |
2005.06.02 |
申请号 |
WO2004IB04421 |
申请日期 |
2004.11.24 |
申请人 |
WESTIN, GUNNAR;BJOERKLUND, PEYMAN;AKERSTROM, GORAN |
发明人 |
WESTIN, GUNNAR;BJOERKLUND, PEYMAN;AKERSTROM, GORAN |
分类号 |
A61K38/00;C07K14/51;C07K14/705;C12N15/85;G01N33/50;G01N33/574 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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地址 |
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