DUAL MOLECULES CONTAINING PEROXY DERIVATIVE, THE SYNTHESIS AND THERAPEUTIC APPLICATIONS THEREOF

摘要

The invention relates to dual molecules of formula (I), wherein A is an antimalarial molecule residue and/or a bioavailability facilitating residue, p, p', p'' are 0 or 1 independent from each other, at least one of p or p'' being equal to 1, identical or different Y1 and Y2 are an alkylene chain possibly containing one or several amine, amide, thioamide, sulfonyl, sulfonate, sulphonamide, carbonyl, thiocarbonyl, carboxyl, thiocarboxyl, ether or thioether radicals, U is an amine, amide, thioamide, sulfonyl, sulfonate, sulphonamide, carbonyl, thiocarbonyl, carboxyl, thiocarboxyl, ether or thioether radical, Z1 and Z2 represent a alkylene radical or Z1+Z2 represent a polycyclic structure, R x and Ry form together a cyclic peroxide comprising from 4 to 8 chain links and contain 1 or 2 additional oxygen atoms in the cyclic structure. A method for producing and using the inventive dual molecules in the form of antimalarial drugs is also disclosed.