The present invention is a pharmaceutical composition that exhibits enhanced IP blood retention, the composition comprising: a biotargeting molecule; and a chelating agent conjugated to the biotargeting molecule; wherein the composition exhibits a half-life in the bloodstream of from 15 minutes to 24 hours. The present invention is also directed to the use of functionalized chelants to modify the pharmacokinetics of radiopharmaceuticals. Compared with non-functionalized chelants, chelants functionalized with bulky and/or lipophilic groups can slow down the renal clearance and enhance the blood retention of metals complexed therewith. This enhanced blood retention leads to increased uptake of metal in target tissue.
申请公布号
WO2005049096(A2)
申请公布日期
2005.06.02
申请号
WO2004US37769
申请日期
2004.11.12
申请人
DOW GLOBAL TECHNOLOGIES INC.;ATHEY, PHILLIP, S.;KIEFER, GARRY, E.;SIMON, JAIME;FRANK, R. KEITH;ADAIR, CHRISTOPHER;GULYAS, GYONGYI
发明人
ATHEY, PHILLIP, S.;KIEFER, GARRY, E.;SIMON, JAIME;FRANK, R. KEITH;ADAIR, CHRISTOPHER;GULYAS, GYONGYI