2-substituted-1,3-thiazole compounds

摘要

The present invention relates to new compounds of formula I, Wherein Y is NR⁴CONR⁴, NR⁴CO, or NR⁴; R¹ is nitro or COR⁵; R² is hydrogen or NH₂; R³ is C_1-6alkyl or C_0-6alkylaryl wherein C_0-6alkylaryl may be substituted by A; R⁴ is hydrogen; R⁵ is C_1-6alkyl; A is independently selected from halo, OR⁶ and C_1-6alkyl; R⁶ is C_1-6alkyl; provided that the compound is not N-(4-Methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea as a free base or a salt thereof as well as a process for their preparation, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.