发明名称 |
Process for the preparation of high purity perindopril and intermediates useful in the synthesis |
摘要 |
The invention relates to 1-{2(S)-[1(S)-(ethoxycarbonyl)butylamino]propionyl}-(3aS,7aS)octahydroindol-2(S)-carboxylic acid of the Formula I and the t-butylamine salt of the Formula I' thereof free of contaminations derivable from dicyclohexyl carbodiimide, and a process for the preparation thereof. The invention also relates to new intermediates of the general Formula III (wherein R stands for lower alkyl or aryl lower alkyl). The compound of the Formula I-perindopril-is a known ACE inhibitor.
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申请公布号 |
US2005119492(A1) |
申请公布日期 |
2005.06.02 |
申请号 |
US20040503272 |
申请日期 |
2004.07.29 |
申请人 |
SIMIG GUYLA;MEZEI TIBOR;PORCS-MAKKAY MARTA;MANDI ATTILA |
发明人 |
SIMIG GUYLA;MEZEI TIBOR;PORCS-MAKKAY MARTA;MANDI ATTILA |
分类号 |
A61K31/404;A61P9/12;A61P43/00;C07D209/42;(IPC1-7):C07D209/42;A61K31/405 |
主分类号 |
A61K31/404 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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