发明名称 |
VECTORS, MUTANT VIRUSES AND METHODS FOR GENERATING MUTANT VIRUSES |
摘要 |
A nucleic acid vector comprising first and second nucleotide sequences corresponding to nucleotide sequences flanking an insertion site in the genome of a selected herpes simplex virus strain; and a cassette located between said first and second nucleotide sequences comprising nucleic acid encoding: (a) one or a plurality of insertion sites and/or a nucleotide sequence of interest; and (b) a ribosome binding site or a regulatory nucleotide sequence; and (c) a marker is disclosed. Herpes simplex viruses generated using said vector, methods for their generation and herpes simplex viruses having a genome comprising heterologous nucleic acid are also disclosed. |
申请公布号 |
WO2005049844(A2) |
申请公布日期 |
2005.06.02 |
申请号 |
WO2004GB04839 |
申请日期 |
2004.11.17 |
申请人 |
CRUSADE LABORATORIES LIMITED;BROWN, SUSANNE MOIRA;DUNN, PAUL;CONNER, JOE |
发明人 |
BROWN, SUSANNE MOIRA;DUNN, PAUL;CONNER, JOE |
分类号 |
A61K35/76;A61K48/00;C12N7/00;C12N15/113;C12N15/869 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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