发明名称 |
ANTIBODY SPECIFIC TO CENTRAL NERVOUS SYSTEM TAU PROTEIN |
摘要 |
The present invention provides an antibody which specifically recognizes a CNS tau protein but not a peripheral tau protein. More specifically, the present invention provides an antibody obtainable by using a polypeptide comprising an amino acid sequence of a connective portion between the amino acid sequence encoded by Exon 4 of a gene encoding a tau protein and the amino acid sequence encoded by Exon 5 thereof as an epitope specific to the isoform of tau protein predominantly existing in central nervous tissues. The present invention further provides a method of detecting Alzheimer's disease and a reagent kit using the antibody. |
申请公布号 |
EP1535930(A1) |
申请公布日期 |
2005.06.01 |
申请号 |
EP20030788111 |
申请日期 |
2003.08.14 |
申请人 |
MITSUBISHI CHEMICAL CORPORATION;MITSUBISHI KAGAKU IATRON, INC. |
发明人 |
OHNO, HIDETO;ISHIGURO, KOICHI;IMAGAWA, MASAKI |
分类号 |
C07K16/18;G01N33/53;G01N33/567;G01N33/68;(IPC1-7):C07K16/18 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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