发明名称 |
Electrical detectors for microanalysis |
摘要 |
Apparatus and methods for performing microanalysis of particles using a microelectrical-mechanical system (MEMS) chip to electrically interrogate the particles. The MEMS chip is typically manufactured using known lithographic micromachining techniques, employed for example, in the semiconductor industry. A substrate carries a plurality of microelectrodes disposed in a detection zone and spaced apart along an axis of a microchannel. The microchannel is sized in cross-section to cause particles carried by a fluid to move past the electrodes in single file. Impedance is measured between one or more pairs of electrodes to determine the presence of a particle in the detection zone. In certain embodiments used in cell manipulation, an electroporation signal may be applied between one or more pairs of electrodes to enhance permeability of a cell membrane. A structural arrangement may be provided to introduce a treatment substance into the microchannel in the vicinity of a cell, which may be restrained for a period of time in a treatment zone.
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申请公布号 |
US2005118705(A1) |
申请公布日期 |
2005.06.02 |
申请号 |
US20040983219 |
申请日期 |
2004.11.05 |
申请人 |
RABBITT RICHARD D.;AYLIFFE H. E. |
发明人 |
RABBITT RICHARD D.;AYLIFFE H. E. |
分类号 |
B01L3/00;C12M1/34;C12Q1/68;G01N15/12;H01L29/08;H01L35/24;(IPC1-7):C12Q1/68 |
主分类号 |
B01L3/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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