发明名称 |
ANTIBODIES AGAINST CANCER |
摘要 |
An isolated binding partner of a Cripto-1 protein, Pim-1 protein or an antigen present in a colon cancer cell lysate is described. The binding partner inhibits growth of one or more cancer cell types and may be used in an anti-cancer agent for treating cancer in a subject. The binding partner may also be used in a method of inducing apoptosis in a cancer cell, as well as in a method of sensitizing a cancer cell to a cytotoxic compound. In addition, a cancer vaccine is described wherein the vaccine comprises a Cripto-1 protein (or an antigenic fragment thereof), Pim-1 protein (or an antigenic fragment thereof) or an antigen present in a colon cancer cell lysate or, alternatively, comprises an expressible DNA molecule encoding a Cripto-1 protein (or an antigenic fragment thereof), Pim-1 protein (or an antigenic fragment thereof) or an antigen present in a colon cancer cell lysate. |
申请公布号 |
EP1383801(A4) |
申请公布日期 |
2005.06.01 |
申请号 |
EP20020706533 |
申请日期 |
2002.03.26 |
申请人 |
THE AUSTIN RESEARCH INSTITUTE |
发明人 |
MCKENZIE, IAN;XING, PEI-XIANG |
分类号 |
C12P21/08;A61K38/00;A61K39/00;A61K39/395;A61K47/48;A61K48/00;A61P35/00;C07K14/47;C07K16/30;(IPC1-7):C07K16/30;A61K38/18;C07K16/22 |
主分类号 |
C12P21/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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