6-Fluorobicyclo[3.1.0]hexane derivatives

摘要

An antidepressant comprising, as an active ingredient, a compound having an antagonistic effect on group II metabotropic glutamate receptors, as well as a 2-amino-3-alkoxy-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative of Formula [I]: [wherein R¹ and R², which may be the same or different, each represent a hydroxyl group, a C_1-10 alkoxy group, etc.; R³ represents a C_1-10 acyl group, a C_1-6 alkoxy-C_1-6 acyl group, etc.; and R⁴ and R⁵, which may be the same or different, each represent a hydrogen atom, a C_1-10 alkyl group, etc.] or a pharmaceutically acceptable salt or hydrate thereof.