| 摘要 |
The present invention relates to a process for preparing piperidine derivative compounds of formulae (I, II), wherein n is 0 or 1; R1is hydrogen or hydroxy; R2is hydrogen; or, when n is 0, R1and R 2taken together form a second bond between the carbon atoms bearing R1and R2, provided that when n is 1, R1and R2are each hydrogen; R3is -COOH or - COOR4; R4is an alkyl or aryl moiety; A, B, and D are the substituents of their rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, alkoxy, and other substituents. The process comprises providing a regioisomer of formula (III), wherein Z is -CG1G2G3(IV) or (V), m is an integer from 1 to 6; Q and Y are the same or different and are selected from the group consisting of O, S and NR5; G1, G2, and G3are the same or different and are selected from the group consisting of OR 8, SR8, and NR8R9; R6and R7are the same or different and are selected from the group consisting of hydrogen, an alkyl moiety, an aryl moiety, OR8, SR8, and NR8R9; and R5, R8, and R9 are the same or different and are selected from the group consisting of hydrogen, an alkyl moiety, and an aryl moiety and converting the regioisomer to the piperidine derivative compound with a piperidine compound.
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