发明名称 |
MODIFIED SACCHARIDES, CONJUGATES THEREOF, AND THEIR MANUFACTURE |
摘要 |
Saccharide-protein conjugates having a new type of linker are described. The conjugates comprising the new linker are prepared from modified saccharides comprising a moiety of the formula (I): -A-N(R1)-L-M wherein: A is a bond,—C(O)—or—OC(O)—; R1 is selected from H or C1-C6 alkyl; L is a C1-C12 alkylene group; and M is a masked aldehyde group. The new linker is especially useful for preparing conjugates of Neisseria meningitidis serogroup A saccharide. Conjugates having this new linker have improved immunogenicity compared to other types of conjugates. |
申请公布号 |
EP1534342(A1) |
申请公布日期 |
2005.06.01 |
申请号 |
EP20030791149 |
申请日期 |
2003.09.01 |
申请人 |
CHIRON SRL. |
发明人 |
GIANNOZZI, ALDO;AVERANI, GIOVANNI;NORELLI, FRANCESCO;COSTANTINO, PAOLO |
分类号 |
A61K47/48;C07H13/12;(IPC1-7):A61K47/48;A61K31/715 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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