Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same

摘要

A process for preparing the polyurethane derivative, the process including: providing a polyurethane having a urethane amino moiety, providing a multifunctional linker reagent of a formula: LG-R_L-(FG)_n, wherein n is an integer from 1 to 3, FG is a functional group, which is a halogen, a carboxyl group, a sulfonate ester, or an epoxy group, LG is a leaving group, which is a halogen, a carboxyl group, a sulfonate ester, or an epoxy group, and R_L is an (n+1)-valent organic radical having at least one carbon atom; providing a protected thiol-containing reagent of a formula R-C(O)SH, or a salt thereof, wherein R is a C₁ to C₆ alkyl group; reacting the multifunctional linker reagent with the urethane amino moiety to form a polyurethane substituted with at least one substituent group of a formula: -R_L-(FG)_n; reacting the polyurethane with a protected thiol-containing reagent to form the polyurethane derivative.