发明名称 |
PHENYLALANINE DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY |
摘要 |
<p>The present invention relates to compounds of formula (I) wherein R, R1 R2 and R3 have the meanings reported in the description, processes for their preparation and pharmaceutical compositions containing them as active ingredients. The compounds of formula (I) are endowed with mixed ACE-inhibitory and NEP-inhibitory activity and are useful for treating cardiovascular diseases.</p> |
申请公布号 |
RO119882(B1) |
申请公布日期 |
2005.05.30 |
申请号 |
RO19980001109 |
申请日期 |
1996.12.17 |
申请人 |
ZAMBON GROUP S.P.A. |
发明人 |
PELLACINI FRANCO;FANTUCCI MARIO;NORCINI GABRIELE;ROMAGNANO STEFANO;SANTANGELO FRANCESCO;SEMERARO CLAUDIO |
分类号 |
A61K31/00;A61K31/34;A61K31/341;A61K31/38;A61K31/381;A61K31/425;A61K31/426;A61K31/44;A61K31/4427;A61K31/4439;A61K31/495;A61K31/505;A61P9/00;A61P43/00;C07D213/55;C07D239/26;C07D241/12;C07D277/20;C07D277/30;C07D307/54;C07D333/24;C07D417/12;(IPC1-7):C07D277/30 |
主分类号 |
A61K31/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|