Pyrazole compounds useful as protein kinase inhibitors

摘要

Disclosed are compounds of formula III, wherein: Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl, being optionally substituted, Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered carbocyclo ring, wherein any substitutable carbon on the fused ring formed by Rx and Ry is substituted by oxo or T-R3, R2 and R2' are independently selected from -R, -T-W-R6, or R2 and R2' are taken together to form a fused 5-8 membered, unsaturated or partially unsaturated ring having 0-3 ring heteroatoms selected from nitrogen, oxygen, or sulfur, and the remaining substituents are defined herein. The compounds are used in the manufacture of medicaments for the inhibition of GSK-3, Aurora, or Src activity.