| 摘要 |
PROBLEM TO BE SOLVED: To provide a new 2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penam-3α-carboxylic acid benzhydryl ester (TMPB)-acetone crystal for use in producing 2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penam-3α-carboxylic acid 1,1-dioxide benzhydryl ester (TAZB). SOLUTION: The invention relates to a process for producing the TMPB-acetone crystal which comprises (A) a step concentrating an organic solvent solution containing TMPB, (B) a step dissolving the resultant concentrate in acetone, and (C) a step crystallizing TMPB-acetone crystals from the acetone solution obtained. And the invention relates to a process for producing TAZB which comprises a reaction of the TMPB-acetone crystals with an oxidizing agent. COPYRIGHT: (C)2005,JPO&NCIPI
|
