发明名称 |
Chemical peptide ligation with three or more components |
摘要 |
The invention provides a method of assembling oligopeptide intermediates in a native chemical ligation reaction that eliminates self-ligation of bi-functional intermediates. An important aspect of the invention is a bi-functional intermediate with an N-terminal heterocyclic protecting group which effectively prevents self-ligation in the chemical assembly process. The present invention is useful in methods for convergent synthesis of polypeptides and proteins and improve,s; the efficiency of native chemical ligation reactions, particularly where three or more peptide fragments are used to assemble a polypeptide or protein product.
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申请公布号 |
US2005113563(A1) |
申请公布日期 |
2005.05.26 |
申请号 |
US20040494928 |
申请日期 |
2004.10.18 |
申请人 |
BOTTI PAOLO;GAERTNER HUBERT;MANGANIELLO SONIA;VILLAIN MATTEO |
发明人 |
BOTTI PAOLO;GAERTNER HUBERT;MANGANIELLO SONIA;VILLAIN MATTEO |
分类号 |
C07K1/06;C07K1/02;C07K1/04;C07K1/107;C07K14/00;(IPC1-7):C07K1/02 |
主分类号 |
C07K1/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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